What You Will Learn In This Post
- Coffee: Nature’s Depression Antidote
- A Cup of Joe Can Protect You From Alzheimer
- Coffee Can Lower The Risk of Type 2 Diabetes
- The Magic Power of Coffee Against Parkinson’s
- Reduce The Risk of Certain Type of Cancer
1. Coffee: Nature’s Depression Antidote
However, in terms of the advantages and dangers of caffeine, the medical world is split. Its mental health impact is the subject of heated discussions. Many believe caffeine can alleviate depression, while others warn that it can make depression worse.
This paper will try to look at both sides of the discussion while analyzing the impacts on depression that other foods have.
Medical studies of the connection between consumption of caffeine and depression, especially when eaten in coffee and tea, often reveal that caffeine can decrease depression incidence. Some even suggest that caffeine may reduce suicide incidence.
Between 1980 and 2015, studies in China found that depression associated with caffeine was relatively low, affecting in all cases less than 1 percent of people.
Studies also showed that when people increased their daily intake of caffeine, the risk of depression as a result of caffeine intake actually decreased.
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But coffee can have other mood advantages that just raise mood shortly after consumption. Numerous smaller studies have shown that coffee can help prevent mild to moderate depression, a disorder in high-income countries that affects 15 percent of people.
More recently, researchers at the Chinese Qingdao University School of Medicine conducted a meta-analysis of the results of 15 of the previously conducted studies analyzing the correlation between coffee consumption and depression.
The findings of the meta-analysis released in the March 2016 problem of the Australian and New Zealand Psychiatry Journal indicate that the probability of developing depression per average cup of caffeinated coffee consumed per day is eight percent smaller.
We still don’t know how coffee helps to relieve the disorder of depression. But two prospective mechanisms are suggested by scientists.
While depression is often seen as the result of low serotonin levels in the brain, a new hypothesis is emerging. Depression is the consequence of a poor immune reaction, which creates inflammation in the brain, according to this hypothesis.
Chinese researchers speculate that coffee can help relieve this type of inflammation because of its special antioxidant combination, which includes chemicals such as chlorogenic acid, nicotinic acid, trigonelline, quinolinic acid, tannic acid, pyrogalic acid.
Another hypothesis is that caffeine is a direct consequence of the antidepressant consequences of caffeinated coffee consumption. Caffeine is a psychostimulant that can increase motivation and wakefulness.
When we wake up and wake up after a nice night’s sleep, the central nervous system has very little adenosine. Adenosine accumulates slowly, though, for several hours without sleep. Adenosine activates receptors of adenosine that cause somnolence and absence of motivation and energy.
By increasing serotonin and dopamine, caffeine stimulates the central nervous system and acts as an antidepressant; it has even been shown in the Archives of Internal Medicine to reduce suicide rates. Some experiences gained more mood than others. Many people are self-medicating depression with caffeine without knowing it. How do you understand if you do this rather than just receiving a useful stimulus?
Some advice: Eat more than four caffeinated beverages a day, including teas and dietary sodas. Or you keep increasing your intake of caffeine to feel less depressed, but it loses its efficacy. I am in favor of maximizing coffee’s therapeutic benefits to alleviate low-level depression, but sometimes when this emotion persists I may need other approaches.
You can prevent your consumption of caffeine to figure out if you are self-medicating depression. It’s not always an easy experiment after a month (most withdrawal symptoms, including headache and fatigue, will be over by then) if you’re noticeably more depressed without caffeine. Also consider the various therapies addressed in this section to boost or replace coffee if you find that you are self-medicated. However, by merely drinking up to three cups a day, mild depressions can react well. (Try spacing them; caffeine stays four to six hours in the system). Moreover, the side effects increase and the chances of tolerance and addiction increase: you consume large amounts.
These findings suggest that the risk of depression is reduced in coffee, not caffeine. A 10-year study also found a link between lower suicide risk and consumption of caffeinated coffee.
Looking at the consumption of caffeine in kids and adolescents, the risk of depression among graders 5 and 10 was discovered to boost. Caffeine has a negative sleep impact that may affect the mood of a person.
Along with a person’s age and sensitivity to caffeine, the type of caffeinated drink may also play a role.
2. A Cup of Joe Can Protect You From Alzheimer
Previously, drinking coffee was associated with a lower risk of dementia and Parkinson’s disease, and scientists now say they have some ideas about why. Researchers at the Robert Wood Johnson Rutgers School of Medicine discovered in a study recently published in the National Academy of Sciences ‘ Proceedings that a fatty acid called Eicosanoil-5-hydroxytryptamide (EHT)— a substance found in coating Waxy coffee beans — protects mice’s brains from disease.
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When EHT was coupled with caffeine, the scientists discovered that the combination of compounds enhanced the activity of a catalyst that helps avoid the accumulation of damaging proteins connected with Parkinson’s disease and Lewy bodies ‘ dementia, one of the most prevalent forms of dementia.
The only protective compounds in coffee are also EHT and caffeine. It also turns out that phenylindanes ‘ chemical compounds formed during the brewing process also inhibit the growth of proteins associated with degenerative brain diseases. And the darker the roast, the more protective compounds in each cup are said by researchers.
Researchers at the Krembil Brain Institute in Toronto analyzed the chemical components of three different Starbucks Via instant coffee samples for another recent study published in Frontiers in Neuroscience: light roasting, dark roasting and dark roasting decaffeinated. They then exposed each sample’s extracts to two protein kinds, beta amyloid and tau, known to be characteristic of Alzheimer’s and Parkinson’s disease. Studies have shown that these proteins tend to form groups (called amyloid plaques and tau protein clews) in the brain as these conditions progress.
The three coffee extracts prevented these proteins from “clustering,” suggesting that a favorite morning drink in the United States could protect against progression of disease. And because the scientists did not notice any distinction in the efficacy of regular versus decaffeinated beers, they determined that these advantages are likely not provided by caffeine.
A fresh research is researching why, besides promoting it every morning, coffee can deter illnesses such as Alzheimer’s and Parkinson’s.
The research was carried out by the Toronto-based Krembil Brain Institute, part of the Krembil Research Institute. In the past, a lower risk of Alzheimer’s has been associated with drinking coffee. In 2009, a group of 1,409 people studied for 21 years by Swedish and Danish researchers. They found that people who drank three to five cups of coffee a day were 65 percent less likely than those who drank two or less cups to develop dementia.
Caffeine, the biomarker associated with Alzheimer’s disease, has been shown to reduce levels of beta-amyloid plaques in animals. Coffee consumption also reduces the risk of type 2 diabetes and vascular disease, two dementia risk factors that may cause the disease to skyrocket.
But all these studies have a significance of observation, demonstrate correlation, not causation. All we know is that coffee drinkers appear to be at a lower risk for certain diseases, not that coffee is the reason behind the lower risks. This is why this Toronto team wanted to investigate what coffee is about which the brain seems to be protected.
“Coffee consumption appears to correlate with a reduced danger of Alzheimer’s disease and Parkinson’s disease,” claims Dr. Donald Weaver, co-director of the Krembil Brain Institute. “But we wanted to investigate why this is, what compounds are involved and how cognitive impairment related to age can be affected.”
Three different types of roast-light roast, dark roast and decaffeinated dark roast were analyzed by the team. To determine whether caffeine affects the risk of Alzheimer’s, they used both caffeinated and decaffeinated coffee versions.
“In our original experimental trials, dark roasting with caffeine and decaffeinated had identical powers,” said Dr. Ross Mancini, a medical chemistry investigator. “So we observed from the beginning that caffeine could not be responsible for its protective effect.”
The team recognized something called phenylindanes in their inquiry, a by-product of the roasting method. Phenylindans prevent the grouping together of both beta-amyloid and tau, the other major biomarker in Alzheimer’s disease. “That’s how phenylindans are a double inhibitor. We didn’t expect that,” said Weaver.
“It’s the first time someone is investigating how phenylindans interact with Alzheimer’s and Parkinson’s proteins,” Mancini said. “The next stage would be to examine how useful these compounds are and whether they are capable of entering the bloodstream or crossing the blood brain barrier.”
If researchers are able to isolate such a compound, it may be helpful to treat or prevent dementia. But much more study is required before phenylindans for the use of medicinal drugs can be regarded.
“What this study does is take epidemiological evidence and try to refine it and show that coffee components are actually beneficial in preventing cognitive impairment,” said Weaver. “It’s interesting, but do we suggest a cure for coffee? Absolutely not.”
Most studies indicate that regular life-long coffee / caffeine intake decreases the danger of developing AD, but some studies demonstrate variable outcomes, especially in the elderly. It seems that before the onset of the disease, i.e. during the pre-morbid phase, coffee / caffeine consumption may be particularly beneficial.
There have been a series of meta-analyzes and reviews that together support the opinion that coffee consumption is connected with a lower risk of AD.
Other studies, however, did not show a link between coffee consumption and a decreased risk of AD. There was no connection between coffee consumption and dementia or cognitive impairment in both a Finnish study and the Honolulu-Asia Aging Study.
Several animal studies point to possible action mechanisms behind coffee / caffeine impacts on AD danger.
In one study, caffeine in drinking water was given to transgenic mice that developed AD-like symptoms around the age of 8 months, improved learning and memory, and reduced peptide A and preseniline concentration in the hippocampus, the main brain structure involved in memory.
Furthermore, these effects were also found when caffeine treatment began late, that is, once the mice had developed cognitive deficits already. By reducing inflammation mediators, caffeine seemed to work.
3. Coffee Can Lower The Risk of Type 2 Diabetes
Type 2 diabetes occurs when the body is no longer able to generate enough insulin or efficiently use the hormone. The result may be too high blood glucose levels.
Some 30.3 million people in the United States are estimated to have diabetes. Type 2 diabetes is the most common form of diabetes, representing approximately 90 to 95% of all cases.
Previous research has shown that drinking coffee can help reduce the risk of type 2 diabetes. Although some studies attributed this connection to the impacts of caffeine, the well-known coffee stimulant, other studies have suggested that drugs may be at risk. Drink alternatives.
Three compounds discovered in coffee appear to block a protein’s toxic accumulation due to an enhanced danger of type 2 diabetes.
“We found that this toxic process can be reversed by three major coffee compounds and can explain why drinking coffee is associated with a lower risk of type 2 diabetes,” says researcher Kun Huang, PhD, Professor of Biological Pharmacy at Huazhong Technology University.
Previous studies have found that individuals who drink four or more cups of coffee a day have a 50% lower risk of developing type 2 diabetes.
Previous studies have found that the most common type of type 2 diabetes is people who drink four or more cups of coffee a day. The body does not have enough insulin in those who have it or the cells ignore insulin. The pancreas-produced hormone insulin is crucial for moving glucose to energy cells.
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Other scientists have connected the “wrong folding” of a protein called hIAPP with an enhanced danger of diabetes. HIAPP is similar to Alzheimer’s disease’s amyloid protein, says Huang. When these deposits of HIAPP accumulate, they can cause pancreatic cell death, Huang says WebMD.
In order to stop the toxic accumulation of protein, the Chinese researchers analyzed three main active compounds in coffee:
“We exposed hIAPP to coffee extracts and found that caffeine, caffeic acid and chlorogenic acid inhibited toxic hIAPP amyloid formation and protected pancreatic cells,” Huang told WebMD.
These findings suggest that decaffeinated coffee also reduces risk, Huang says. “The percentage of caffeine acid and chlorogenic acid content in decaffeinated coffee is even higher than in normal coffee, whereas the level of caffeine is greatly reduced.”
“In comparison with regular caffeinated types, we expect decaffeinated coffee to have at least an equal or even greater beneficial effect,” says Huang.
Several studies suggest that decaffeination is better for them than normal coffee in patients who already have diabetes, he says.
Boston, MA–According to a fresh research led by scientists from the Harvard School of Public Health (HSPH), people who increased the quantity of coffee they drank each day in more than one cup over a four-year period had an 11% reduced risk of type 2 diabetes than those who did not change their coffee intake. Furthermore, the research discovered that those who reduced their intake of coffee by more than one cup per day increased their risk of type 2 diabetes by 17%.
“Our results confirm those from past research that indicated a lower risk of type 2 diabetes associated with greater coffee consumption,” said Shilpa Bhupathiraju, lead author and investigator at the HSPH Nutrition Department. “Most importantly, they provide fresh proof that changes in coffee consumption habits in a comparatively brief span of time can impact the risk of type 2 diabetes.”
In the Nurses Health Study II (1991-2007), 27,759 men in the Health Professionals Follow-up Study (1986-2006) and 48,464 women in the Nurses Health Study at Brigham and Women’s Hospital (1986-2006), the researchers analyzed data on caffeinated and decaffeinated coffee and caffeinated tea consumption. A questionnaire was used to evaluate the diets of participants every four years, and additional questionnaires were completed by those who reported type 2 diabetes. There have been recorded a total of 7,269 instances of type 2 diabetes.
The findings showed that respondents who increased their coffee consumption by more than one cup per day (mean change= 1.69 cups per day) over a four-year period had an 11 percent lower risk of type 2 diabetes four years later compared to those who did not alter their consumption. (A cup of coffee was defined as eight ounces, black or some milk and/or sugar). Those who lowered their daily consumption of coffee by more than one cup (average change= 2 cups / day) had an increased danger of diabetes of 17 percent. Changes in decaffeinated coffee consumption and caffeinated tea consumption have not been associated with changes in type 2 diabetes risk.
“These findings show that coffee can have health benefits for most people,” said Frank Hu, HSPH’s lead author and nutrition and epidemiology professor. “But coffee is just one of the many variables that affect the risk of diabetes. Most importantly, individuals should monitor their weight and be active physically.”
4. The Magic Power of Coffee Against Parkinson’s
The disease of Parkinson (PD) is a weakening neurodegenerative disorder. Nearly 1.2 million people in Europe are estimated to have PD, with about 75,000 new cases being diagnosed each year. The onset age of PD is usually over 60 years, but one in 10 cases is estimated to be diagnosed before age 50, with slightly more males than females impacted.
PD’s cardinal characteristics are motor function deceleration, resting tremor, muscle stiffness, gait disturbance, and postural reflex deterioration. Progressive destruction of dopaminergic neurons in the midbrain is the underlying pathological lesion. Currently, there is no treatment available to prevent or slow this neuronal loss and the resulting decrease in midbrain dopamine.
Experimental and epidemiological research concentrated on risk variables for lifestyle, diet and the environment, including coffee consumption.
A big amount of epidemiological studies report an inverse relationship, the dose-response between consumption of coffee / caffeine and the risk of developing PD. Consumption of coffee appears to decrease or delay the growth of PD and caffeine is likely the cause. The relationship between caffeine and hormone therapy still requires further clarification in females, however.
One research recorded in the control a greater proportion of non-coffee customers relative to the impacted group47 as early as 1968. Subsequent studies in Spain48, Sweden49, and Germany50 revealed an inverse relationship between coffee consumption and PD and lower coffee consumption prior to disease onset.
The first prospective study, undertaken for an average period of 27 years, of 8,004 Japanese American males residing in Hawaii (the Honolulu Heart Program), revealed an inverse connection between the incidence of PD with a five-fold lower risk for those who consume more than 4 cups of coffee per day compared to non-users. Caffeine from sources other than coffee51 showed the same inverse relationship. A smaller case-control study published in 2014 suggested only a weak inverse association between coffee intake and the risk of PD52.
There have been a series of meta-analyzes and reviews that together support the opinion that coffee consumption is connected with a lower risk of Parkinson’s disease.
The data is more misleading in women. One research discovered a U-shaped connection, the most protective of which was mild coffee / caffeine consumption57-59. The use of postmenopausal hormones appears to have an effect on the danger of PD from coffee consumption.
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Harvard University Staff Writer Alvin Powell claims that for years, Harvard researchers had coffee under the microscope and last year announced the discovery of six fresh coffee-related human genes, reconfirming the presence of two earlier recognized genes. The long-running Harvard Nurses Health Study discovered that coffee has protective properties against type 2 diabetes and cardiovascular disease, and researchers are revisiting a research in 2001 finding that it can also safeguard against Parkinson’s disease.
Meanwhile, Harvard T.H. Chan School of Public Health teacher of epidemiology and nutrition and Harvard Medical School lecturer Alberto Ascherio studied the possible antiparkinsonic impacts of coffee that were first indicated in the results of the 2001 research. That research, of which Dr. Ascherio was the lead author, showed that drinking four or five cups of coffee a day lowers the danger of creating Parkinson’s disease by nearly half compared to eating little or nothing of caffeine.
The research was released in the Annals of Neurology, entitled “Prospective study on caffeine consumption and risk of Parkinson’s disease in males and females” (Ann Neurol. 2001 Jul; 50(1): 56-63), co-authoredby Dr. Ascherio with SM Zhang, MA Hernn, I. Kawachi, G.A. Colditz, F.E. Speizer and W.C. Willett, who noted that while the results of case-control studies and prospective research suggest that consumption of coffee can protect against the risk of Parkinson’s disease (PD), the active element is uncertain, so in order to tackle the hypothesis that caffeine protects against Parkinson’s disease, the respondents in two continuing cohorts, the Health Professionals Follow-Up Study (HPFS) and the Nurses Health Study (NHS), examined the connection between coffee and caffeine consumption with the danger of PD.
The research population included 47,351 disease-free males from Parkinson and 88,565 females who were also baseline free of, stroke, or cancer. Baseline study respondents finished a extensive lifestyle and nutritional questionnaire and updated every two to four years.
Drinking coffee has been associated with a decreased danger of Parkinson’s disease (PD) development for years. In fact, a study carried out in 1968 suggested that coffee drinkers were less like getting PD (Nefzger, Quadfasel & Karl, 1968). The PD / coffee link has since been verified by numerous epidemiological research (Ascherio et al., 2003; Ascherio et al., 2004; Fujimaki et al., 2018). The protective effect was mostly attributed to the caffeine component by researchers (Lee et al., 2013).
All papers of the Science News summarize a survey of studies and are not an official view, approval or stance of the Parkinson Foundation.
5. Reduce The Risk of Certain Type of Cancer
For centuries, researchers have been researching the connections between coffee and cancer. But they still don’t know a lot. In 2016, an expert committee convened by the International Cancer Research Agency (IARC), the World Health Organization’s arm responsible for evaluating whether certain substances cause cancer, could not conclude that drinking coffee is carcinogenic according to current proof.
And now the connection between coffee and cancer is again in the news. A decision on a coffee alert linked to a chemical created during the roasting process (called acrylamide) by the California tribunal last week raised concerns among customers.
So what do you need to understand about coffee drinkers? Researchers from the American Cancer Society, Susan Gapstur, PhD, and Marjorie McCullough, ScD, provide data in this interview on what studies to date really show when it comes to coffee and cancer, and discuss what further study still needs to be done.
Numerous studies have shown that drinking coffee from all causes of death is associated with a lower risk of dying. However, there is no clear association with cancer in general or with particular cancer kinds. In 2016, an expert working group for the International Agency for Research on Cancer Monographs Program assessed the worldwide human and laboratory studies body on coffee consumption and cancer risk and discovered proof of coffee consumption carcinogenicity to be “unclassifiable.”
They also found that drinking coffee is not a cause of cancer of the breast, pancreas, and female prostate, but may reduce the risk of endometrial cancer of the uterus and liver. The evidence for other types of cancer was found to be inadequate. The reasons why there was no compelling proof included inconsistent outcomes between research and data quality issues.
Recent studies have found that coffee can decrease the risk of several kinds of cancer, including head and neck, colorectal, breast and liver disease, although it does not fully understand the potential positive impacts of coffee. Roasted coffee contains hundreds of biologically active compounds including caffeine, flavonoids, lignans and other polyphenols.
These and other coffee compounds, among other operations, have been shown to boost energy expenditure, inhibit cell damage, control genes engaged in DNA repair, have anti-inflammatory characteristics and/or inhibit metastasis. There is also evidence that coffee consumption is associated with a lower risk of insulin resistance and type 2 diabetes associated with higher risk of colorectal, liver, breast and endometrial cancer incidence and/or mortality.
In numerous studies, researchers have demonstrated the anti-cancer and anti-inflammatory properties of coffee. (Although some studies have not found associations between coffee consumption and cancer risk reduction). In a meta-analysis, researchers compared people with low coffee intake with those with high coffee consumption. The researchers found that coffee reduced liver cancer by 54%, oral and pharyngeal cancer by 31%, endometrial cancer by 27%, colon cancer by 13%, prostate cancer by 11% and melanoma in 11%.
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Caffeine. Thanks to caffeine, which can precipitate carcinogens through the digestive tract, coffee can reduce the risk of colorectal cancer, thus reducing intestinal exposure to them. Caffeine may also have antioxidant characteristics and may restrict colon cancer cells ‘ development and migration. Caffeine affected cell signaling in cell research, which suppressed cell growth and enhanced colorectal cancer cells apoptosis.
Researchers studying decaffeinated coffee, however, discovered that it also decreases the danger of colon cancer, showing that caffeine is not the only active coffee compound.
Caffeic acid Researchers have found that caffeic acid has inhibitory characteristics of anti-inflammatory, anti-cancer and enzyme. Caffeic acid, like other coffee polyphenols, shows antitumor activity.